Solutions for cell and gene therapy manufacturing
Advancing gene therapy scale-up & manufacturing
Gene Therapy Research
Gene therapies can provide significant — and possibly curative — benefits to patients who have genetic or acquired diseases. Through the direct expression of a therapeutic protein or by restoring the expression of an under-expressed protein, gene therapy uses vectors to deliver gene-based drugs and therapeutic loads to patients.
It is a complex process to maintain the integrity and activity of the gene therapy product, particularly when scaling up to commercial production. We offer a broad range of cGMP chemicals and fluid handling technologies to help you develop gene therapies that can reach patients faster; from cell culture components, fermentation media and supplements to growth factors, reagents and excipients. Through careful planning and collaboration, the experienced team at Avantor® designs customized solutions that are agile, scalable and fit for purpose.
This flexibility is due in part to our open-architecture approach utilizing high quality and modular fluid handling technologies. Avantor’s extensive product knowledge and broad applications experience — with experienced scientists at Innovation Centers across the globe — leverage better workflow technologies and quality risk management to improve productivity.
If regulatory bottlenecks, product loss and supply disruptions are slowing you down, engage with Avantor to scale up safely and efficiently — reducing waste, costs and contamination risk.
Advancing gene therapy by solving challenges in scale-up & manufacturing
Latest Q&A with Ger Brophy, Avantor Executive Vice President, Biopharma Production with new insight on gene therapy
Gene therapy manufacturing
At Avantor, we work together to maximize efficiencies, mitigate risk and reduce waste, so you can scale up quickly and safely to meet speed to market demands.
Upstream processing
You can achieve the optimal generation of gene therapy vectors with Avantor’s non-viral transfection and viral transduction products. Our cell culture systems and fluid handling solutions support process development, scale up, and complete manufacturing. We offer a variety of gene therapy products, including:
- Transfection and electroporation products
- Viral vector generation kits
- Animal sera
- Fluid handling products
- Sterile cell factories
Downstream purification
Avantor J.T.Baker® brand cGMP chemicals and BAKERBOND® chromatography resins have been successfully used in commercial and clinical manufacturing of protein therapeutics for decades. We offer our expertise in chromatography and downstream process optimization with services including:
- Column packing
- Process development support
- Custom chromatography resins
- Column cleaning
- Storage recommendations
Final fill
To progress from a drug substance to a final drug product requires the correct packaging vials and stoppers and a broad range of excipients that meet many stringent quality requirements. Avantor partners with you to match your therapy with appropriate gene therapy products and materials.
Fluid handling solutions
Our fluid handling solutions, including Avantor Masterflex® peristaltic pumps, tubing and single-use components, are custom designed for flexibility and versatility in aseptic fluid handling across the upstream, downstream, and final-fill steps of producing cell therapies.
Our proprietary Avantor Adjustable Volume Sampling System (AVSS) and Exact Volume Sampling System (EVSS) are designed to aseptically draw a precise small sample volume from your most critical applications. These single use, closed system solutions eliminate the need for a biologic hood are available as standard products or are fully customizable to your exact specifications.
Environmental control
Maintaining aseptic conditions during the manufacturing or down packing process is part of managing your risk. We offer products from industry-leading manufacturers and support from our teams of specialists who have the technical and industry experience to recommend the best solutions to meet your needs.
Gene therapy products
Optimize your workflow with our innovative gene therapy products and solutions. Avantor provides compliant materials that include:
- Cell culture media and sera
- Plasmid transfection and T-cell transduction reagents
- Expansion and purification chemicals
- High purity and excipients
- Single-use fluid connectivity, sampling and sterile transfer
We also offer tailored innovative solutions to help you solve process challenges. These include:
- Customized single-use solutions
- Custom-packaged buffers and excipients
- Customized formats for media, sterile solutions, excipients and preservation reagents
Explore our portfolio of cGMP chemicals, single-use solutions, sera and more on vwr.com.
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