Solutions for mAbs manufacturing
Improving mAb manufacturing productivity by optimizing buffer and media prep process flow
Monoclonal antibodies (mAbs) are at the forefront of the biological products market. They will continue to lead resource investment in the biopharmaceutical industry to help provide innovative therapeutic solutions for immune-oncology and immunotherapy.
Avantor® offers an industry-leading portfolio of upstream, downstream, and drug product bioprocessing solutions. Our solutions help you maintain mAbs quality, activity, and stability throughout the entire process.
Improving mAb manufacturing productivity
Flexible, cost-efficient infrastructure and on-time delivery of buffers are required to meet process demands in mAbs manufacturing. Single-use delivery systems, in powder or liquid form, can help accomplish these goals while reducing the risk of contamination, among other benefits.
Fluid handling solutions
Avantor supports every stage of your mAbs manufacturing process with fluid handling technologies, including single-use components, connectors, and assemblies as well as Masterflex® peristaltic pumps for aseptic fluid handling and storage. Our experts collaborate to design customized solutions that meet your exact process and compliance requirements, utilizing a global supply network for security and convenience.
Upstream processing
Our fully characterized products for upstream processing of mAbs are designed to support cell growth, consistency, and productivity while meeting the required quality and performance parameters. Avantor’s commitment to using an open architecture design of single-use assemblies allows the seamless transfer from process development to pilot scale and final commercial manufacturing.
Downstream purification
Our industry-leading Avantor J.T.Baker® brand buffer product line and J.T.Baker® BAKERBOND™ chromatography resins, including the BAKERBOND® PROchievA™ recombinant protein A resin, are trusted for high performance in mAbs manufacturing. We also provide downstream optimization services, including column packing and process development support to streamline your operations.
Final fill
Avantor offers the highest purity excipients you need to progress from drug substance to final drug product, including adjuvants, stabilizers, preservatives, and bulking agents used in drug product formulation to minimize drug product degradation. We also offer packaging vials and stoppers that meet stringent internal and external quality requirements.
Single-use solutions
Avantor supports every stage of your mAbs manufacturing process with single-use technologies, including components, connectors, and assemblies for aseptic fluid handling and storage in upstream, downstream, fill and finish process steps.
Environmental control
Maintaining aseptic conditions during the manufacturing or down packing process is part of managing your risk. We offer products from industry-leading manufacturers and support from our teams of specialists who have the technical and industry experience to recommend the best solutions to meet your needs.
How can we help?
Avantor’s solutions, combined with our experience and insights into bioprocessing optimization, can help biopharma manufacturers increase mAb titers, mAb fragments that can be manufactured in other expression systems, multiple target specificity for mAbs, and the development of Antibody-Drug Conjugates (ADCs) that deliver drugs to targeted cancer cells.
Our portfolio includes mission-critical products and services that support every stage of your process, from monoclonal antibodies research to production. We have a global infrastructure that serves more than 225,000 customer locations worldwide. Let us improve your bioproduction efficiencies so you can focus on scientific breakthroughs.
Avantor's hydration solutions:
Avantor is the ideal partner to develop innovative, customized, buffer solutions that save you time, resources, and money.
Explore our mAbs manufacturing products
Start optimizing your process performance with our innovative products and single-use solutions for mAbs production:
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